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Associations among High-Quality Protein and Energy Intake, Serum Transthyretin, Serum Amino Acids and Linear Growth of Children in Ethiopia

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dc.contributor.author Tessema, Masresha
dc.contributor.author S. Gunaratna, Nilupa
dc.contributor.author D. Brouwer, Inge
dc.contributor.author Donato, Katherine
dc.contributor.author L. Cohen, Jessica
dc.contributor.author McConnell, Margare
dc.contributor.author Belachew, Tefera
dc.contributor.author Belayneh, Demissie
dc.contributor.author De Groote, Hugo
dc.date.accessioned 2023-01-03T11:24:10Z
dc.date.available 2023-01-03T11:24:10Z
dc.date.issued 2018-11-16
dc.identifier.citation Tessema, Masresha, Nilupa S. Gunaratna, Inge D. Brouwer, Katherine Donato, Jessica L. Cohen, Margaret McConnell, Tefera Belachew, Demissie Belayneh, and Hugo De Groote. 2018. "Associations among High-Quality Protein and Energy Intake, Serum Transthyretin, Serum Amino Acids and Linear Growth of Children in Ethiopia" Nutrients 10, no. 11: 1776. en_US
dc.identifier.uri http://ephispace.ephi.gov.et/xmlui/handle/123456789/521
dc.description.abstract Limited evidence is available on the associations of high-quality protein and energy intake, serum transthyretin (TTR), serum amino acids and serum insulin-like growth factor-1 (IGF-1) with linear growth of young children. Data collected during the baseline of a randomized control trial involving rural Ethiopian children aged 6–35 months (n = 873) were analyzed to evaluate the associations among height/length-for-age z-scores, dietary intakes, and these biomarkers (i.e., serum level of TTR, IGF-1, tryptophan and lysine, and inflammation). The prevalence of stunting was higher for children >23 months (38%) than ≤23 months (25%). The prevalence of inflammation was 35% and of intestinal parasites 48%. Three-quarters of the children were energy deficient, and stunted children had lower daily energy intake that non-stunted children (p < 0.05). Intakes of tryptophan, protein, and energy, and serum levels of tryptophan and IGF-1 were positively correlated with the linear growth of children. Controlling for inflammation, intestinal parasites, and sociodemographic characteristics, daily tryptophan (b = 0.01, p = 0.001), protein (b = 0.01, p = 0.01) and energy (b = 0.0003, p = 0.04) intakes and serum TTR (b = 2.58, p = 0.04) and IGF-1 (b = 0.01, p = 0.003) were positively associated with linear growth of children. Linear growth failure in Ethiopian children is likely associated with low quality protein intake and inadequate energy intake. Nutrition programs that emphasize improved protein quantity and quality and energy intake may enhance the linear growth of young children and need to be further investigated in longitudinal and interventional studies. en_US
dc.language.iso en en_US
dc.publisher MDPI en_US
dc.subject PROTEIN INTAKE en_US
dc.subject PROTEIN QUALITY en_US
dc.subject ENERGY INTAKE en_US
dc.title Associations among High-Quality Protein and Energy Intake, Serum Transthyretin, Serum Amino Acids and Linear Growth of Children in Ethiopia en_US
dc.type Journal Article en_US
ep.contributor.affiliation Division of Human Nutrition, Wageningen University, 6700 AA Wageningen, The Netherlands; inge.brouwer@wur.nl en_US
ep.contributor.affiliation Ethiopian Public Health Institute, Gulele Sub City, P.O. Box 1242, Addis Ababa, Ethiopia en_US
ep.contributor.affiliation Human Nutrition Unit, Jimma University, P.O. Box 378, Jimma, Ethiopia; teferabelachew@gmail.com en_US
ep.contributor.affiliation Department of Nutrition Science and Public Health Graduate Program, Purdue University, West Lafayette, IN 47907, USA; gunaratna@purdue.edu en_US
ep.contributor.affiliation Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA; katherinedonato@fas.harvard.edu (K.D.); cohenj@hsph.harvard.edu (J.L.C.); mmcconne@hsph.harvard.edu (M.M.) en_US
ep.contributor.affiliation International Maize and Wheat Improvement Centre (CIMMYT), P.O. Box 5689, Addis Ababa, Ethiopia; D.Belayneh@cgiar.org en_US
ep.contributor.affiliation International Maize and Wheat Improvement Centre (CIMMYT), P.O. Box 1041-00621, Nairobi, Kenya; h.degroote@cgiar.org en_US
ep.identifier.status Open Access en_US
ep.identifier.doi https://doi.org/10.3390/nu10111776 en_US
ep.journal Nutrients en_US
ep.issue 11 en_US
ep.volume 10 en_US


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