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Applying international guidelines for calcium supplementation to prevent pre-eclampsia: simulation of recommended dosages suggests risk of excess intake in Ethiopia

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dc.contributor.author Tesfaye, Biniyam
dc.contributor.author Sinclair, Kate
dc.contributor.author E Wuehler, Sara
dc.contributor.author Moges, Tibebu
dc.contributor.author De-Regi, Luz Maria
dc.contributor.author L Dickin, Katherine
dc.date.accessioned 2022-12-30T14:05:53Z
dc.date.available 2022-12-30T14:05:53Z
dc.date.issued 2018-10-15
dc.identifier.citation Tesfaye, B., Sinclair, K., Wuehler, S., Moges, T., De-Regil, L., & Dickin, K. (2019). Applying international guidelines for calcium supplementation to prevent pre-eclampsia: Simulation of recommended dosages suggests risk of excess intake in Ethiopia. Public Health Nutrition, 22(3), 531-541. doi:10.1017/S1368980018002562 en_US
dc.identifier.uri http://ephispace.ephi.gov.et/xmlui/handle/123456789/519
dc.description.abstract Objective: To simulate impact of Ca supplementation on estimated total Ca intakes among women in a population with low dietary Ca intakes, using WHO recommendations: 1·5–2·0 g elemental Ca/d during pregnancy to prevent pre eclampsia. Design: Single cross-sectional 24 h dietary recall data were adjusted using IMAPP software to simulate proportions of women who would meet or exceed the Estimated Average Requirement (EAR) and Tolerable Upper Intake Level (UL) assuming full or partial adherence to WHO guidelines. Setting: Nationally and regionally representative data, Ethiopia’s ‘lean’ season 2011. Subjects: Women 15–45 years (n 7908, of whom 492 pregnant). Results: National mean usual Ca intake was 501 (SD 244) mg/d. Approximately 89, 91 and 96 % of all women, pregnant women and 15–18 years, respectively, had dietary Ca intakes below the EAR. Simulating 100 % adherence to 1·0, 1·5 and 2·0 g/d estimated nearly all women (>99 %) would meet the EAR, regardless of dosage. Nationally, supplementation with 1·5 and 2·0 g/d would result in intake exceeding the UL in 3·7 and 43·2 % of women, respectively, while at 1·0 g/d those exceeding the UL would be <1 % (0·74 %) except in one region (4·95 %). Conclusions: Most Ethiopian women consume insufficient Ca, increasing risk of pre-eclampsia. Providing Ca supplements of 1·5–2·0 g/d could result in high proportions of women exceeding the UL, while universal consumption of 1·0 g/d would meet requirements with minimal risk of excess. Appropriately tested screening tools could identify and reduce risk to high Ca consumers. Research on minimum effective Ca supplementation to prevent pre-eclampsia is also needed to determine whether lower doses could be recommended. en_US
dc.language.iso en en_US
dc.publisher online by Cambridge University Press en_US
dc.subject CALCIUM SUPPLEMENTATION en_US
dc.subject PREGNANCY en_US
dc.subject PRE-ECLAMPSIA en_US
dc.title Applying international guidelines for calcium supplementation to prevent pre-eclampsia: simulation of recommended dosages suggests risk of excess intake in Ethiopia en_US
dc.type Journal Article en_US
ep.contributor.affiliation Ethiopia Public Health Institute, Food Science and Nutrition Research Directorate, Addis Ababa, Ethiopia en_US
ep.contributor.affiliation Micronutrient Initiative Contractor, Montreal, Quebec, Canada: en_US
ep.contributor.affiliation Nutrition International (formerly the Micronutrient Initiative), Global Technical Services, 180 Elgin Street, Suite 1000, Ottawa, Ontario, Canada, K2P 2K3 en_US
ep.contributor.affiliation Cornell University, Division of Nutritional Sciences, Ithaca, New York, NY, USA en_US
ep.identifier.status Open Access en_US
ep.identifier.doi DOI: https://doi.org/10.1017/S1368980018002562 en_US
ep.journal Public Health Nutrition en_US
ep.issue 3 en_US
ep.volume 22 en_US


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