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Use of partial N-gene sequences as a tool to monitor progress on rabies control and elimination efforts in Ethiopia

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dc.contributor.author Binkley, Laura
dc.contributor.author Deressa, Asefa
dc.contributor.author Shi, Mang
dc.contributor.author Jara, Manuel
dc.contributor.author E. Escobar, Luis
dc.contributor.author R. Mauldin, Mathew
dc.contributor.author Matheny, Audrey
dc.contributor.author O’Quin, Jeanette
dc.contributor.author G. Pieracci, Emily
dc.contributor.author Kling, Chantal
dc.contributor.author Hartloge, Yimer
dc.contributor.author Abate, Ebba
dc.contributor.author Gebreyes, Wondwossen
dc.contributor.author Reynolds, Mary
dc.contributor.author Belay, Ermias
dc.contributor.author Shiferaw, Miriam
dc.contributor.author Nakazawa, Yoshinori
dc.contributor.author Velasco-Villa, Andres
dc.date.accessioned 2022-12-09T13:40:37Z
dc.date.available 2022-12-09T13:40:37Z
dc.date.issued 2021-09
dc.identifier.citation Laura Binkley, Asefa Deressa, Mang Shi, Manuel Jara, Luis E. Escobar, Mathew R. Mauldin, Audrey Matheny, Jeanette O'Quin, Emily G. Pieracci, Chantal Kling, Claire Hartloge, Getnet Yimer, Ebba Abate, Wondwossen Gebreyes, Mary Reynolds, Ermias Belay, Miriam Shiferaw, Yoshinori Nakazawa, Andres Velasco-Villa, Use of partial N-gene sequences as a tool to monitor progress on rabies control and elimination efforts in Ethiopia, Acta Tropica en_US
dc.identifier.uri http://ephispace.ephi.gov.et/xmlui/handle/123456789/492
dc.description.abstract Ethiopia is one of the African countries most affected by rabies. A coarse catalog of rabies viruses (RABV) was created as a benchmark to assess the impact of control and elimination activities. We evaluated a 726 bp amplicon at the end of the N-gene to infer viral lineages in circulation using maximum likelihood and Bayesian methods for phylogenetic reconstruction. We sequenced 228 brain samples from wild and domestic animals collected in five Ethiopian regions during 2010–2017. Results identified co-circulating RABV lineages that are causing recurrent spillover infections into wildlife and domestic animals. We found no evidence of importation of RABVs from other African countries or vaccine-induced cases in the area studied. A divergent RABV lineage might be involved in an independent rabies cycle in jackals. This investigation provides a feasible approach to assess rabies control and elimination efforts in resource-limited countries. en_US
dc.language.iso en en_US
dc.publisher Elsevier B.V. en_US
dc.subject DOG RABIES en_US
dc.subject CO-CIRCULATING LINEAGESRESOURCE en_US
dc.subject MONITORING ELIMINATION en_US
dc.title Use of partial N-gene sequences as a tool to monitor progress on rabies control and elimination efforts in Ethiopia en_US
dc.type Journal Article en_US
ep.contributor.affiliation Centers for Disease Control and Prevention, 1600 Clifton Rd. NE, Atlanta, GA 30333, USA en_US
ep.contributor.affiliation Ethiopian Public Health Institute, Gulele Sub City, Addis Ababa, Ethiopia en_US
ep.contributor.affiliation Ohio State University Global One Health Initiative, Columbus, OH, USA en_US
ep.contributor.affiliation Centre for Infection and Immunity Studies, School of Medicine, Sun Yat-Sen University, Guangzhou, China en_US
ep.contributor.affiliation Department of Population Health and Pathobiology, College of Veterinary Medicine, North Carolina State University, Raleigh, NC, USA en_US
ep.contributor.affiliation Department of Fish and Wildlife Conservation, Virginia Polytechnic Institute and State University, Blacksburg, VA 24601, USA en_US
ep.identifier.status Open Access en_US
ep.identifier.doi https://doi.org/10.1016/j.actatropica.2021.106022 en_US
ep.journal Acta Tropica en_US
ep.volume 221 en_US


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