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Prognostic factors and outcomes of COVID-19 cases in Ethiopia: multi-center cohort study protocol

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dc.contributor.author Abdella, Saro
dc.contributor.author Tessema, Masresha
dc.contributor.author Tasew, Geremew
dc.contributor.author Defar, Atkure
dc.contributor.author Deressa, Asefa
dc.contributor.author Regasa, Feyisa
dc.contributor.author Teka, Frehiwot
dc.contributor.author Tigabu, Eyasu
dc.contributor.author Nigussie, Dereje
dc.contributor.author Belachew, Tefera
dc.contributor.author Molla, Million
dc.contributor.author Deribew, Amare
dc.contributor.author Abebe, Workeabeba
dc.contributor.author Yigzaw, Tegbar
dc.contributor.author Nigatu, Tsinuel
dc.contributor.author Mitike, Getnet
dc.contributor.author Haile, Tewodros
dc.contributor.author Taame, Haftom
dc.contributor.author Ahmed, Muhammed
dc.contributor.author Nigatu, Frehiwot
dc.contributor.author Tolesa, Tola
dc.contributor.author Wolka, Eskinder
dc.contributor.author Amogne, Wondwossen
dc.contributor.author Laillou, Arnaud
dc.contributor.author Amare, Misker
dc.contributor.author Fufa, Yaregal
dc.contributor.author Argaw, Alemayehu
dc.contributor.author Waganew, Woldesenbet
dc.contributor.author Azazh, Akilili
dc.contributor.author Worku, Aschalew
dc.contributor.author Redae, Berhane
dc.contributor.author Sultan, Menbeu
dc.contributor.author Walelegn, Miraf
dc.contributor.author Tefera, Muluwork
dc.contributor.author Yifru, Sisay
dc.contributor.author Argaw, Rahel
dc.contributor.author Brehau, Natinael
dc.contributor.author Teklu, Sisay
dc.contributor.author Demoz, Getachew
dc.contributor.author Seman, Yakob
dc.contributor.author Salasibew, Mihretab
dc.contributor.author Ejeta, Eshetu
dc.contributor.author J. Whiting, Susan
dc.contributor.author Wolday, Dawit
dc.contributor.author Tollera, Getachew
dc.contributor.author Abate, Ebba
dc.contributor.author Duguma, Dereje
dc.date.accessioned 2022-12-08T14:17:59Z
dc.date.available 2022-12-08T14:17:59Z
dc.date.issued 2021-09-16
dc.identifier.citation Abdella, S., Tessema, M., Tasew, G. et al. Prognostic factors and outcomes of COVID-19 cases in Ethiopia: multi-center cohort study protocol. BMC Infect Dis 21, 956 (2021). en_US
dc.identifier.uri http://ephispace.ephi.gov.et/xmlui/handle/123456789/490
dc.description.abstract Background: The coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus (SARS-CoV-2) and became pandemic after emerging in Wuhan, China, in December 2019. Several studies have been conducted to understand the key features of COVID-19 and its public health impact. However, the prognostic factors of COVID-19 are not well studied in the African setting. In this study, we aim to determine the epidemiological and clinical features of COVID-19 cases, immunological and virologic courses, interaction with nutritional status, and response to treatment for COVID-19 patients in Ethiopia. Methods: A multi-center cohort study design will be performed. Patients with confirmed COVID-19 infection admitted to selected treatment centers will be enrolled irrespective of their symptoms and followed-up for 12 months. Baseline epidemiological, clinical, laboratory and imaging data will be collected from treatment records, interviews, physical measurements, and biological samples. Follow-up data collection involves treatment and prognostic out comes to be measured using different biomarkers and clinical parameters. Data collection will be done electronically using the Open Data Kit (ODK) software package and then exported to STATA/SPSS for analysis. Both descriptive and multivariable analyses will be performed to assess the independent determinants of the treatment outcome and prognosis to generate relevant information for informed prevention and case management. The primary outcomes of this study are death/survival and viral shedding. Secondary outcomes include epidemiological characteristics, clinical features, genetic frequency shifts (genotypic variations), and nutritional status. Discussion: This is the first large prospective cohort study of patients in hospitals with COVID-19 in Ethiopia. The results will enable us to better understand the epidemiology of SARS-CoV-2 in Africa. This study will also provide en_US
dc.language.iso en en_US
dc.publisher EPHI en_US
dc.subject PROGNOSTIC FACTORS en_US
dc.subject OUTCOMES OF COVID en_US
dc.subject COHORT en_US
dc.title Prognostic factors and outcomes of COVID-19 cases in Ethiopia: multi-center cohort study protocol en_US
dc.type Journal Article en_US
ep.contributor.affiliation Ethiopian Public Health Institute, Addis Ababa, Ethiopia en_US
ep.identifier.status Open Access en_US
ep.identifier.doi https://doi.org/10.1186/s12879-021-06652-0 en_US
ep.journal BMC Infectious Diseases en_US
ep.issue 1 en_US
ep.volume 21 en_US


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