Institutional Repository

Plasma Levels of Viro-Immunological Markers in HIV-Infected and Noninfected Ethiopians:Correlation With Cell Surface Activation Markers

Show simple item record

dc.contributor.author Messele,Tsehaynesh
dc.contributor.author Brouwer,Margreet
dc.contributor.author Girma,Mulu
dc.contributor.author L. Fontanet ,Arnaud
dc.contributor.author Miedema,Frank
dc.contributor.author Hamann,Dorte
dc.contributor.author Rinke de Wit,Tobias F.
dc.date.accessioned 2022-11-24T10:12:28Z
dc.date.available 2022-11-24T10:12:28Z
dc.date.issued 01/01/2001
dc.identifier.citation Messele T, Brouwer M, Girma M, Fontanet AL, Miedema F, Hamann D, Rinke de Wit TF. Plasma levels of viro-immunological markers in HIV-infected and non-infected Ethiopians: correlation with cell surface activation markers. Clin Immunol. 2001 Feb;98(2):212-9.
dc.identifier.uri http://172.21.6.100:8080/xmlui/handle/123456789/114
dc.description.abstract Cross-sectional studies were conducted to measure soluble viral and immunological markers in plasma in order to determine the prognostic value of these markers for HIV disease progression in Ethiopians and to see their association with cell surface markers in HIV-1-infected and noninfected Ethiopians. Whole blood samples were collected from 52 HIV-1-negative Ethiopians, 32 HIV-1-positive Ethiopians with absolute CD4(+) T-cell count >200/microl whole blood and no AIDS defining conditions, and 39 HIV-positive Ethiopians with CD4(+) T-cell count <200/microl and/or AIDS defining conditions. Plasma levels of b(2)-microglobulin (b(2)m), soluble CD27 (sCD27), soluble tumor necrosis factor alpha receptor type II (sTNFR-II), IgG, IgA, IGE, and IL12 were elevated in HIV-1-infected individuals. The plasma levels of sTNFR-II, sCD27, b(2)m, IL12, and IgG were inversely correlated with numbers of CD4(+) T-cells, the proportion of naïve (CD45RA(+)CD27(+)) CD8(+) T-cells, and the proportion of CD8(+) T-cells expressing CD28 (CD8(+)CD28(+)) were positively correlated with the proportions of activated (HLA-DR(+)CD38(+)) CD4(+) T-cells, as well as activated (HLA-DR(+)CD38(+)) CD8(+) T-cells. A strong positive correlation was also observed when soluble immune markers were compared to each other. Multivariate regression analyses of soluble markers with numbers of CD4(+) T-cells showed that sCD27 is the best independent marker for CD4(+) T-cell decline in the HIV-1-infected Ethiopians. Our results indicate that measurement of soluble immune markers, which is relatively easy to perform, could be a good alternative to the quantification of T-cell subsets for monitoring HIV-1 disease progression in places where there is no facility for flow cytometric measurements.
dc.format.extent 212-219
dc.subject HIV-1ETHIOPIANS
dc.subject sCD27
dc.subject sTNFR-II
dc.subject Β2M
dc.subject IL12
dc.subject IgG
dc.subject IgE
dc.subject IgA
dc.title Plasma Levels of Viro-Immunological Markers in HIV-Infected and Noninfected Ethiopians:Correlation With Cell Surface Activation Markers
dc.type Journal Article
ep.identifier.status Limited Access
ep.identifier.status Limited Access
ep.identifier.doi https://doi.org/10.1006/clim.2000.4958
ep.journal Clinical Immunology
ep.issue 2
ep.volume 98


Files in this item

Files Size Format View

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record

Search DSpace


Advanced Search

Browse

My Account