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Primary resistance to anti-tuberculesis drugs in Addis Ababa, Ethiopia

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dc.contributor.author Demissie,Meaza
dc.contributor.author Gebeyehu,M
dc.contributor.author Berhanu , Y.
dc.date.accessioned 2022-11-24T10:11:08Z
dc.date.available 2022-11-24T10:11:08Z
dc.date.issued 1994
dc.identifier.citation Meaza. Demissie ; M. gebeyehu, Y.Berhanu. Primary resistance to anti-tuberculosis drugs in Addis Ababa, Ethiopia.international journal of Tuberclosis lung disease, 1994, issue 1,volume 1.PP-64-67
dc.identifier.uri http://172.21.6.100:8080/xmlui/handle/123456789/92
dc.description.abstract Objective: To obtain current, representative information on current drug resistance patterns in Addis Ababa, Ethiopia. Design: A cross-sectional study whereby 167 isolates were tested for susceptibility to the anti-tuberculosis drugs commonly used in the country (isoniazid, thiacetazone, rifampicin, streptomycin and ethambutol). All hospitals, health centres and 6 of the 9 clinics in Addis Ababa were included in the study. Result: Overall primary drug resistance was found to be 15.6% (26/167). Primary resistance to two or more drugs was 7.2% (12/167). The highest rate of primary resistance was to streptomycin (10.2%) followed by isoniazid (8.4%). Resistance to rifampicin was low (1.8%, 3/167) and to ethambutol nil. Multiple drug resistance in combinations with rifampicin was low. Conclusion: To prevent further development and spread of resistance, universal use of standard treatment protocol, control of the circulation of anti-tuberculosis drugs, training of health workers, expansion of strictly supervised short-course treatment and establishing a nation-wide and regular surveillance system are recommended
dc.format.extent 64-67
dc.subject Drug resistance
dc.subject tuberculosis
dc.subject Ethiopia
dc.title Primary resistance to anti-tuberculesis drugs in Addis Ababa, Ethiopia
dc.type Journal Article
ep.identifier.status Limited Access
ep.identifier.status Limited Access
ep.journal International journal of tuberculosis lung disease,
ep.issue 1
ep.volume 1


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