In vitro activity of some fluoroquinolones and other unrelated antimicrobial agents against bacterial enteric pathogens

Abstract

The in-vitro activity of ofloxacin, lomefloxacin, ciprifloxacin, fleroxacin, DR-335, and PD-127391 which are all members of the fluoroquinolones and other unrelated (classical) antimicrobials that include, amoxycillin, sulphamethoxazole, trimethoprim, tetracycline and chloramphenicol have been compared against Salmonella typhi, campylobacter jejuni, Yersinia enterocolitica, Vibrio cholerae, Aeromonas hydrophila, and Vibrio parahaemolyticus. Minimum inhibitory concentrations (MICs) of the antimicrobial agents examined were determined. All members of the fluoroquinolones were highly active against all insolates examined and inhibited them at a concentration of <1mg/L. By contrast, many of the isolates examined were resistant to one or more of the classical antimicrobial agents. These results showed a potential clinical role for all the fluoroquinolone compounds tested in the treatment or prophylaxis of bacterial enteric infections where antimicrobial intervention is indicated.